Biphenyl → HCID 178469464, compound

Participants

Reaction Steps

A solution of 85 g of the mixture of cyclooctanone and diethyl N-(1-cyclooctenyl)-aminomethylenemalonate in 20 ml. of Dowtherm® (a eutectic mixture of diphenyl ether and biphenyl) is added to 380 ml. Dowtherm® at 250°-255° under nitrogen. The distillate is collected in a water separator. After 0.5 hour the mixture is cooled to room temperature and solvent is removed under reduced pressure. The residual solid is triturated with ether to give ethyl 5,6,7,8,9,10-hexahydro-4-hydroxycycloocta[b]pyridine-3-carboxylate, m.p. 219°-222°.

Provenance & Evidence