Sodium Hydroxide → HCID 23699212, compound

HRID 1761565Notes

Reaction equation

HRID 1761565 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[N:11]=[C:10]([CH2:21][CH2:22][C:23]([OH:25])=[O:24])[CH:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+:27]>>[OH2:19].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[N:11]=[C:10]([CH2:21][CH2:22][C:23]([O-:25])=[O:24])[CH:9]=2)=[CH:6][CH:7]=1.[Na+:27]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 1888503-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]propanoic Acid

Product 1

HCID 23699212HCID 23699212, compoundYield 98%

Procedure

To the acid 12 (1.0169 g, 2.85 mM) was added a 1.00N NaOH solution (2.85 ml, 2.85 mM) and distilled H2O (15 ml). The reaction mixture was stirred until it was homogeneous, and then lyophilized to afford 13 (1.08 g, 98%) as a white solid, with a mp greater than 300° C.

Workup

  1. distillationdistilled H2O (15 ml)

Sources & evidence

ORD record
ord-7e84057d5a37496d839020890d24aca3
Source dataset
uspto-grants-1989_05
Patent number
US04826868

Reaction notes

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