Benzoyl chloride, 3-nitro- → HCID 14500623, compound

Participants

Reaction Steps

A solution of 19 g (160 mmol) of 1-butyl-2-ethylpyrrole in 300 ml of toluene was treated with 38 g (200 mmol) of m-nitrobenzoyl chloride. The reaction mixture was refluxed under nitrogen atmosphere for 18 hours, cooled and purified by column chromatography on 1 Kg of deactivated alumina (containing 3% water), using hexane-acetone (90:10) as eluant. There were obtained 13.2 g (35%) of 1-butyl-2-(3'-nitrobenzoyl)-5-ethylpyrrole, the title compound, as an oil.

Provenance & Evidence