HCID 14500623, compound → HCID 14500624, compound

Participants

Reaction Steps

A solution of 11.9 g (39 mmol) of 1-butyl-2-(3'-nitrobenzoyl)-5-ethylpyrrole in 100 ml of methanol was hydrogenated at 45 p.s.i. in the presence of 3 g of 10% palladium-charcoal catalyst for 1 hour. The catalyst was then separated by fltration and the filtrate evaporated under reduced pressure. The residue was purified by column chromatography on 500 g of silica gel, using hexane-acetone (95:5) as eluant, to produce 6.5 g (60%) of 1-butyl-2-(3'-aminobenzoyl)-5-ethylpyrrole, the pure title compound, which was recrystallized from hexane. M.P. 71°-7° C.

Provenance & Evidence