HCID 14500642, compound → HCID 14500643, compound

Participants

Reaction Steps

A solution of 19 g (80 mmol) of 1-butyl-2-(3'-nitrobenzoyl)pyrrole in 250 ml of methanol was hydrogenated at 45 p.s.i. in the presence of 3 g of a 10% palladium-charcoal catalyst. After 45 minutes the catalyst was separated by filtration and the filtrate evaporated under reduced pressure. Purification of the residue by column chromatography on 750 g of silica gel, using hexane-ethyl acetate (75:25) as eluant, afforded 16.6 g (95%) of 1-butyl-2-(3'-aminobenzoyl)pyrrole, the title compound, as an oil.

Provenance & Evidence