Ipriflavone → Ipriflavon beta-cyclodextrin

Participants

Reaction Steps

11.0 g (39.2 mmoles) of Ipriflavon and 114.3 g (88.3 mmoles) of β-cyclodextrin of 12.36% moisture content, were dissolved in 2.25 liters of 50% by volume aqueous ethanol solution at 80° C. under vigorous stirring and left to cool to room temperature. The crystalline product precipitated was filtered and dried for 24 hours at 60° C. to give 96.4 g of product in form of loose, white powder. The particle size is smaller than 90 μm. Ipriflavon content: 10.8% by weight; Ipriflavon: -β-cyclodextrin ratio=1:2; Yield related to the active ingredient: 94.7%.

Provenance & Evidence