Ipriflavone → Ipriflavon gamma-cyclodextrin

Participants

Reaction Steps

0.5 g (1.78 mmoles) of Ipriflavon were dissolved in 50 ml of 96% ethanol and the solutions thus obtained was added dropwise to the solution of 8.0 g (5.35 mmoles) of γ-cyclodextrin of 13.3% moisture content in 50 ml of distilled water, during 2 hours, then the mixture left to cool to room temperature. After a further 16-hour intensive stirring the product obtained was filtered and dried for 24 hours at 60° C. to give 5.5 g of product. Ipriflavon content: 7.9% by weight, molar ratio of Ipriflavon:γ-cyclodextrin=1:2.29. Yield related to the active ingredient: 87%. The product also contains free cyclodextrin.

Provenance & Evidence