N-(5-chloro-4-fluoro-2-nitrophenyl)acetamide → 5-Chloro-4-fluoro-2-nitroaniline

Participants

Reaction Steps

A solution of N-(3-chloro-4-fluoro-6-nitrophenyl)acetamide (30 g) in concentrated hydrochloric acid (50 ml) and ethanol (200 ml) was refluxed for 2.5 hours. To the reaction mixture was added ice water (300 ml) and the resulting precipitate was collected by filtration, washed with water and dried to give the title compound (24.9 g) as yellow needles, mp 149.5°-150° C.

Provenance & Evidence