HCID 14552383, compound → HCID 14552384, compound

Participants

Reaction Steps

Ethyl 8-[(phenylmethyl)amino]-1,4-dioxaspiro[4.5]-decane-7-carboxylate (397.2 g, 1.3 mole) was combined with 2563 ml of ethanol and 80 g of 5% palladium on activated carbon and hydrogenated at 50 p.s.i. for 6 hours at 45°-50° C. The catalyst was separated by filtration, and the filtrate was evaporated. When taken up in methylene chloride a semi-solid precipitated and was filtered out. The filtratew was evaporated to yield 277.7 g (97.4%) of the title product.

Provenance & Evidence