HCID 21242097, compound → HCID 21242102, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-phenyl-3-[4-(2-tetrahydropyranyloxyethyl)-1-piperazinyl]-7H-pyrrolo[1,2-a]azepin-7-one (1.5 g) in chloroform (15 cc) and methanol (15 cc), 11.5M aqueous hydrochloric acid solution (1 cc) is added and the mixture is stirred at a temperature of about 20° C. for 12 hours. The solvents are evaporated off and the residue thereby obtained is dissolved in methylene chloride (50 cc). The solution is washed with 1N aqueous sodium hydroxide solution (25 cc) and twice with distilled water (50 cc in total), dried over anhydrous magnesium sulphate in the presence of decolorizing charcoal, filtered and evaporated to dryness under reduced pressure (20 mm Hg; 2.7 kPa) at 40° C. 3-[4-(2-Hydroxyethyl)-1-piperazinyl]-1-phenyl-7H-pyrrolo[1,2-a]azepin-7-one (0.28 g) is thereby obtained in the form of a pale yellow oil.

Provenance & Evidence