Ammonia → HCID 10997097, compound

HRID 1761720Notes

Reaction equation

HRID 1761720 reaction equation
[CH2:1]([N:4]([C:10]([O:12]C)=O)[CH2:5][C:6](OC)=[O:7])[C:2]#[CH:3].[NH3:14]>>[CH2:1]([N:4]1[CH2:5][C:6](=[O:7])[NH:14][C:10]1=[O:12])[C:2]#[CH:3]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 14580243HCID 14580243, compound

Product 1

HCID 10997097HCID 10997097, compound

Procedure

3.0 g of methyl N-propargyl-N-methoxycarbonylglycinate were dissolved in 40 ml of 28% aqueous ammonia. Then the mixture was maintained under the pressure of 10-13 kg/cm2 at 100°-110° C. for an hour. Then the solvent was evaporated off from the reaction mixture. The resulting mixture was subjected to a column chromatography on silica gel (5:1 ethyl acetate:methanol as eluent) to obtain 0.65 g of 1-propargyl-2,4-dioxoimidazolidine.

Workup

  1. temperatureThen the mixture was maintained under the pressure of 10-13 kg/cm2 at 100°-110° C. for an hour
  2. customThen the solvent was evaporated off from the reaction mixture

Sources & evidence

ORD record
ord-4f522af51f2d43db858a99d16f8429f9
Source dataset
uspto-grants-1989_05
Patent number
US04827020

Reaction notes

Loading…