Ammonia → HCID 21242407, compound

HRID 1761721Notes

Reaction equation

HRID 1761721 reaction equation
[CH2:1]([N:4]([C:10]([O:12][CH3:13])=[O:11])[CH2:5][C:6](OC)=O)[C:2]#[CH:3].[NH3:14].C[OH:16]>>[CH2:1]([N:4]([C:10]([O:12][CH3:13])=[O:11])[C:5](=[O:16])[CH2:6][NH2:14])[C:2]#[CH:3]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 887MethanolHCID 14580243HCID 14580243, compound

Product 1

HCID 21242407HCID 21242407, compound

Procedure

3.9 g of methyl N-propargyl-N-methoxycarbonylglycinate were added to the mixture of 100 ml of 28% aqueous ammonia and 10 ml of methanol and stirred for 10 hours at room temperature. Then the solvent was evaporated off from the reaction mixture. The residue was chromatograhed on silica gel to obtain 3.0 g of N-propargyl-N-methoxycarbonylglycinamide (melting point: 77°-80° C.).

Workup

  1. customThen the solvent was evaporated off from the reaction mixture

Sources & evidence

ORD record
ord-57c2b17e3acc44558220749c3bcd723f
Source dataset
uspto-grants-1989_05
Patent number
US04827020

Reaction notes

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