Water → HCID 14875837, compound

Participants

Reaction Steps

A solution of 23.1 g phenol (0.25 moles) and 53.1 g 2-butanone (0.74 moles) is pumped into a CO pressurized reactor containing 10 g water (0.56 moles) and 91 g AHF (4.55 moles). At a starting pressure of 1430 psig and 74°-81° C., the phenol and 2-butanone are charged in (66 minutes pumping time). After complete addition of the reactants, the pressure decreases from 2015 psig to 1700 psig over an additional 188 minutes at the reaction temperature. 8.4 g of (II) is isolated as toluene and methyl isobutyl ketone soluble from an aqueous HF extraction representing 55% phenol conversion and 32% selectivity to (II). Crystallization from toluene and CHCl3 yielded the product (m.p. 129°-131° C.) with structure II verified by nmr.

Provenance & Evidence