HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Nitrophenyl)acetic acid → HCID 54099171, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Nitrophenyl)acetic acid | HCID 4661 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-(4-Hydroxypiperidin-1-yl)benzaldehyde | HCID 12717446 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 54099171 | HCID 54099171 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A one liter three necked flask fitted with a dropping funnel, mechanical stirrer and condenser is charged with 34.35 g of 4-nitrophenylacetic acid. Piperidine (16.2 g) is added dropwise over a period of 30 minutes. At the end of the addition, 38.4 g of 4-(4-hydroxypiperidyl)benzaldehyde is added. The reaction mixture is heated at 100° C. for three hours, and at 130° C. for three hours. After cooling, the semi-solid product mass is ground in ethanol in a blender, then filtered, washed, and vacuum dried. The crude product is recrystallized from chlorobenzene, m.p. 248°-250° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04828758 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-0689847027f34d8788013a56c5872d1b |
| Source note | uspto-grants-1989_05 |