3'-Chloro-4'-octyloxy-4-biphenylcarboxylic acid → Phenyl 3'-chloro-4'-octyloxybiphenyl-4-carboxylate

HRID 1761825Notes

Reaction equation

HRID 1761825 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([OH:25])=[O:24])=[CH:19][CH:18]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].F[C:27]1[CH:28]=[C:29]([CH:38]=[CH:39][C:40]=1O)C(OC[C@@H](C)CC)=O>>[Cl:1][C:2]1[CH:3]=[C:4]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([O:25][C:27]3[CH:28]=[CH:29][CH:38]=[CH:39][CH:40]=3)=[O:24])=[CH:19][CH:18]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Participants

3

Reactant 2

HCID 147941813'-Chloro-4'-octyloxy-4-biphenylcarboxylic acidHCID 54464410(S)-2-methylbutyl 3-fluoro-4-hydroxybenzoate

Product 1

HCID 86743016Phenyl 3'-chloro-4'-octyloxybiphenyl-4-carboxylate

Procedure

The reaction was performed as in Example 18 except using 3'-chloro-4'-octyloxybiphenyl-4-carboxylic acid instead of 3'-nitro-4'-tetradecyloxybiphenyl-4-carboxylic acid and (S)-2-methylbutyl 3-fluoro-4-hydroxybenzoate instead of (S)-2-methylbutyl 4-hydroxybenzoate. There was obtained 2-fluoro-4--(S)-2-methylbutyloxycarbonyl]phenyl 3'-chloro-4'-octyloxybiphenyl-4-carboxylate.

Sources & evidence

ORD record
ord-fa3e305f4f5d410cb072c303c7f03ac3
Source dataset
uspto-grants-1989_05
Patent number
US04828754

Reaction notes

Loading…