2-Chloromethylbenzimidazole → 4-[(1H-benzimidazol-2-ylmethyl)thio]quinazoline

HRID 1761855Notes

Reaction equation

HRID 1761855 reaction equation
[SH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.Cl[CH2:13][C:14]1[NH:15][C:16]2[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=2[N:18]=1>>[N:15]1[C:16]2[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=2[NH:18][C:14]=1[CH2:13][S:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 785712-ChloromethylbenzimidazoleHCID 178527884HCID 178527884, compound

Product 1

HCID 5961554-[(1H-benzimidazol-2-ylmethyl)thio]quinazolineYield 56.5%

Procedure

The title compound(2.5 g) was prepared from 4-mercaptoquinazoline(6.0 g) and 2-chloromethylbenzimidazole (2.52 g).

Sources & evidence

ORD record
ord-aeba22f03fcd48428f51b668f95d2eeb
Source dataset
uspto-grants-1989_05
Patent number
US04829069

Reaction notes

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