1-Chloro-2-(diethylamine)ethane hydrochloride → 4-[2-(Diethylamino)ethylthio]-quinazoline

HRID 1761856Notes

Reaction equation

HRID 1761856 reaction equation
[SH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.Cl.[CH2:13]([N:15]([CH2:18][CH2:19]Cl)[CH2:16][CH3:17])[CH3:14]>>[CH2:13]([N:15]([CH2:18][CH3:19])[CH2:16][CH2:17][S:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1)[CH3:14]

Participants

3

Reactant 2

HCID 133631-Chloro-2-(diethylamine)ethane hydrochlorideHCID 178527884HCID 178527884, compound

Product 1

HCID 200436484-[2-(Diethylamino)ethylthio]-quinazolineYield 59.9%

Procedure

The title compound(4.82 g) was prepared from 4-mercaptoquinazoline(5.0 g) and N,N-diethylaminoethylchloride hydrochloride(5.3 g).

Sources & evidence

ORD record
ord-3f598ef5caff478f9a7e2dc12b17041f
Source dataset
uspto-grants-1989_05
Patent number
US04829069

Reaction notes

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