2-(Chloromethyl)-4-methoxy-5-methylpyridine → 4-[(4-Methoxy-5-methylpyridin-2-yl)methylthio]-quinazoline

HRID 1761863Notes

Reaction equation

HRID 1761863 reaction equation
[SH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.Cl[CH2:13][C:14]1[CH:19]=[C:18]([O:20][CH3:21])[C:17]([CH3:22])=[CH:16][N:15]=1>>[CH3:21][O:20][C:18]1[C:17]([CH3:22])=[CH:16][N:15]=[C:14]([CH2:13][S:1][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[CH:4][N:3]=2)[CH:19]=1

Participants

3

Reactant 2

HCID 144799142-(Chloromethyl)-4-methoxy-5-methylpyridineHCID 178527884HCID 178527884, compound

Product 1

HCID 144799124-[(4-Methoxy-5-methylpyridin-2-yl)methylthio]-quinazolineYield 3.7%

Procedure

The title compound(0.24 g) was prepared from 4-mercaptoquinazoline(3.5 g) and 2-chloromethyl-4-methoxy-5-methylpyridine(4.1 g).

Sources & evidence

ORD record
ord-7c612d9276e84e3f9a1c86624038e102
Source dataset
uspto-grants-1989_05
Patent number
US04829069

Reaction notes

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