2-(Chloromethyl)-4-methoxy-5-methylpyridine → 4-[(4-Methoxy-5-methylpyridin-2-yl)methylthio]-2-methylquinazoline

HRID 1761864Notes

Reaction equation

HRID 1761864 reaction equation
[SH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:12])[N:3]=1.Cl[CH2:14][C:15]1[CH:20]=[C:19]([O:21][CH3:22])[C:18]([CH3:23])=[CH:17][N:16]=1>>[CH3:22][O:21][C:19]1[C:18]([CH3:23])=[CH:17][N:16]=[C:15]([CH2:14][S:1][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[C:4]([CH3:12])[N:3]=2)[CH:20]=1

Participants

3

Reactant 2

HCID 144799142-(Chloromethyl)-4-methoxy-5-methylpyridineHCID 178433539HCID 178433539, compound

Product 1

HCID 144799064-[(4-Methoxy-5-methylpyridin-2-yl)methylthio]-2-methylquinazolineYield 1.5%

Procedure

The title compound(0.12 g) was prepared from 4-mercapto-2-methylquinazoline(4.48 g) and 2-chloromethyl-4-methoxy-5-methylpyridine(6.3 g).

Sources & evidence

ORD record
ord-f6abdc51afc64f66b051f868c827767a
Source dataset
uspto-grants-1989_05
Patent number
US04829069

Reaction notes

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