Dimethylformamide → HCID 70386008, compound

Participants

Reaction Steps

5-(BOC-Phe-Nle-AHCP-aminomethyl)-tetrazole is obtained, analogously to Example 4, from BOC-Phe-OH and 5-(H-Nle-AHCP-aminomethyl)-tetrazole [obtainable by reacting BOC-aminoacetonitrile with NaN3 in DMF in the presence of NH4Cl at 80°-90° to give 5-BOC-aminomethyltetrazole (M.p. 153°-155°), splitting off the BOC group to give 5-aminomethyltetrazole, subjecting the latter to a condensation reaction with BOC-Nle-AHCP-OH to give 5-BOC-Nle-AHCP-aminomethyltetrazole and again splitting off the BOC group].

Provenance & Evidence