2-[N-(4-Methanesulphonamidobenzyl)-N-methylamino]-5-methanesulphonamidoindane → 5-Methanesulphonamido-2-methylaminoindane

HRID 1761874Notes

Reaction equation

HRID 1761874 reaction equation
CS(NC1C=CC([CH2:10][N:11]([CH:13]2[CH2:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([NH:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:19]=3)[CH2:14]2)C)=CC=1)(=O)=O>C(O)C.[Pd]>[CH3:26][S:23]([NH:22][C:18]1[CH:19]=[C:20]2[C:15](=[CH:16][CH:17]=1)[CH2:14][CH:13]([NH:11][CH3:10])[CH2:21]2)(=[O:25])=[O:24]

Participants

4

Reactant 1

HCID 150149922-[N-(4-Methanesulphonamidobenzyl)-N-methylamino]-5-methanesulphonamidoindane

Product 1

HCID 198886595-Methanesulphonamido-2-methylaminoindane

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2-[N-(4-Methanesulphonamidobenzyl)-N-methylamino]-5-methanesulphonamidoindane (0.175 g) in ethanol (20 ml) containing 5% Pd/C (0.02 g) was stirred under a hydrogen atmosphere [275.8 kPa (40 p.s.i.)] for 31/2 hours at 40°. The catalyst was then removed by filtration and the filtrate evaporated to dryness in vacuo to give the title compound as an oil, yield 0.09 g, which was used directly without further purification.

Workup

  1. customThe catalyst was then removed by filtration
  2. customthe filtrate evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-80a760474ce4442d9288e38940bdfc38
Source dataset
uspto-grants-1989_05
Patent number
US04829071

Reaction notes

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