1-[4-(Benzyloxy)benzene-1-sulfonyl]-5-ethoxypyrrolidin-2-one → 5-Ethoxy-1-(4-hydroxybenzene-1-sulfonyl)pyrrolidin-2-one

Participants

Reaction Steps

At 20° C., and under 1000 mbar, 6.3 g of 1-(4-benzyloxyphenylsulphonyl)-5-ethoxypyrrolidin-2-one is hydrogenated in the presence of 1.2 g of catalyst (Pd at 10%), in 150 cm3 of 96° ethanol. After filtering, concentrating the filtrate, and crystallizing the residue from 96° ethanol, 2.5 g of the expected product is obtained, m.p. 162°-163° C.

Provenance & Evidence