5-Ethoxy-1-(4-nitrobenzene-1-sulfonyl)pyrrolidin-2-one → 1-(4-Aminobenzene-1-sulfonyl)-5-ethoxypyrrolidin-2-one

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Reaction Steps

At ambient temperature and pressure, 4.5 g of 1-(4-nitrophenylsulphonyl)-5-ethoxypyrrolidin-2-one, dissolved in 200 cm3 of 96° ethanol is hydrogenated in the presence of palladium at 10% on charcoal. The insoluble matter is filtered off and taken up with hot chloroform, filtered, and the last filtrate is added to the alcohol solution resulting from the first filtration. After re-crystallizing the residue twice from 96° ethanol, 2.3 g of the expected product is obtained, m.p. 185°-186° C.

Provenance & Evidence