HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyamine hydrochloride → 4-Chlorophenyl 1-(1, 2, 4-triazol-1-yl)-cyclopropyl ketone oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 1-(4-Chlorobenzoyl)-1-(1,2,4-triazol-1-yl)cyclopropane | HCID 13650451 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Chlorophenyl 1-(1, 2, 4-triazol-1-yl)-cyclopropyl ketone oxime | HCID 86743019 | 83% |
Reaction Steps
24.8 g (0.1 mol) of 4-chlorophenyl 1-(1, 2, 4-triazol-1-yl)-cyclopropyl ketone were refluxed for 4 hours with 10.4 g of hydroxylamine hydrochloride, 10.6 g of sodium acetate in 200 ml of ethanol and 100 ml of water, the solvent was removed in vacuo, and the crystal slurry obtained was triturated with water. 21.7 g (83%) of the title compound were obtained as colorless crystals of melting point 186°-218° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04829075 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-24102ef0ca3348b8a132add534121a24 |
| Source note | uspto-grants-1989_05 |