反应详情

(1)-(i) A mixture of 420 mg of methyl benzofuran-7-carboxylate, 5 ml of an aqueous 10% sodium hydroxide solution and 5 ml of methanol is stirred at room temperature for 1 hour. The reaction mixture is evaporated to remove solvent. The residue is dissolved in water and the solution is acidified with 10% hydrochloric acid. The resultant crystals are collected by filtration and dried to give 321 mg of benzofuran-7-carboxylic acid as colorless crystals.

1. customThe reaction mixture is evaporated
2. customto remove solvent
3. dissolutionThe residue is dissolved in water
4. filtrationThe resultant crystals are collected by filtration
5. customdried