Sodium Hydroxide → Benzofuran-7-Carboxylic Acid

HRID 1761907Notes

Reaction equation

HRID 1761907 reaction equation
[O:1]1[C:5]2[C:6]([C:10]([O:12]C)=[O:11])=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1.[OH-].[Na+]>CO>[O:1]1[C:5]2[C:6]([C:10]([OH:12])=[O:11])=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14229730Methyl benzofuran-7-carboxylate

Product 1

HCID 13307983Benzofuran-7-Carboxylic AcidYield 83%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(1)-(i) A mixture of 420 mg of methyl benzofuran-7-carboxylate, 5 ml of an aqueous 10% sodium hydroxide solution and 5 ml of methanol is stirred at room temperature for 1 hour. The reaction mixture is evaporated to remove solvent. The residue is dissolved in water and the solution is acidified with 10% hydrochloric acid. The resultant crystals are collected by filtration and dried to give 321 mg of benzofuran-7-carboxylic acid as colorless crystals.

Workup

  1. customThe reaction mixture is evaporated
  2. customto remove solvent
  3. dissolutionThe residue is dissolved in water
  4. filtrationThe resultant crystals are collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-ee157fa10fc94d07a242545f44bb72fa
Source dataset
uspto-grants-1989_05
Patent number
US04829067

Reaction notes

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