HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1761909Generated: October 30, 2026
Sodium Bicarbonate → Methyl 2-(4-aminophenyl)benzofuran-7-carboxylate
https://huagongshe.com/reaction/1761909
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Methyl 2-(4-nitrophenyl)benzofuran-7-carboxylate | HCID 14229713 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Methyl 2-(4-aminophenyl)benzofuran-7-carboxylate | HCID 14229714 | 93.3% |
Reaction Steps
A mixture of 3.1 g of methyl 2-(4-nitrophenyl)benzofuran-7-carboxylate, 11.7 g of stannous chloride dihydrate and 100 ml of ethyl acetate is heated at 70° C. for 1 hour. After cooling, the reaction mixture is alkalized with an aqueous sodium bicarbonate solution and extracted with ethyl acetate. The extract is washed with water, dried and evaporated to remove solvent to give 2.6 g of methyl 2-(4-aminophenyl)benzofuran-7-carboxylate as yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04829067 |
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| Source dataset | uspto-grants-1989_05 |
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| ORD ID | ord-a5c7623183c14b62b81be3b37ab22eab |
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| Source note | uspto-grants-1989_05 |
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