HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1761911Generated: November 2, 2026
Hydrochloric Acid → 2-(4-Dimethylaminophenyl)benzofuran-7-carboxylic acid
https://huagongshe.com/reaction/1761911
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 2-(4-dimethylaminophenyl)benzofuran-7-carboxylate | HCID 14229715 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(4-Dimethylaminophenyl)benzofuran-7-carboxylic acid | HCID 14229716 | 99.3% |
Reaction Steps
920 mg of methyl 2-(4-dimethylaminophenyl)benzofuran-7-carboxylate are dissolved in a mixture of 20 ml of methanol and 20 ml of tetrahydrofuran. 10 ml of an aqueous 1N sodium hydroxide solution are added to the solution and the mixture is heated at 50° C. for 40 minutes. After cooling, the reaction mixture is neutralized with 10% hydrocloric acid and extracted with ethyl acetate. The extract is dried and evaporated to remove solvent to give 870 mg of 2-(4-dimethylaminophenyl)benzofuran-7-carboxylic acid as yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04829067 |
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| Source dataset | uspto-grants-1989_05 |
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| ORD ID | ord-89298c6253404621aebc81862be82b30 |
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| Source note | uspto-grants-1989_05 |
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