反应详情

A mixture of 1.0 g of methyl 2-methylbenzofuran-7-carboxylate, 1.24 g of acetyl chloride, 2.15 g of aluminum chloride and 20 ml of dichloroethane is heated at 50°-60° C. for 1 hour. The reaction mixture is poured into ice-water and the aqueous mixture is extracted with chloroform. The extract is washed with water, dried and evaporated to remove solvent. The residue is recrystallized from ethyl acetate-n-hexane to give 1.08 g of methyl 3-acetyl-2-methylbenzofuran-7-carboxylate as colorless needles.

1. temperatureis heated at 50°-60° C. for 1 hour
2. extractionthe aqueous mixture is extracted with chloroform
3. washThe extract is washed with water
4. customdried
5. customevaporated
6. customto remove solvent
7. customThe residue is recrystallized from ethyl acetate-n-hexane