Bromine → HCID 14500293, compound

HRID 1761967Notes

Reaction equation

HRID 1761967 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])=[CH:4][CH:3]=1.[Br:17]Br>C(Cl)(Cl)Cl>[Br:17][CH:8]([C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1)[C:9]([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:10]

Participants

4

Reactant 2

HCID 24408Bromine2×HCID 2363292-(4-fluorophenyl)-1-phenylethanone

Product 1

HCID 14500293HCID 14500293, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
0 °C

Procedure

At room temperature, to 20 g (0.093 mol) of α-(p-fluorophenyl)-acetophenone in 200 ml of chloroform, are added a few drops of a charge of 4.8 ml of bromine (0.93 mol) (a deep orange-color results). The resultant solution is heated to initiate reaction (the solution turns yellow), and then cooled to 0° C., and the balance of the 4.8 ml of bromine is added dropwise. The reaction mixture is stirred at room temperature for about 16 hours.

Workup

  1. customorange-color results)
  2. customreaction (the solution

Sources & evidence

ORD record
ord-27108cabac124aa9b2a76c0a42495d77
Source dataset
uspto-grants-1989_05
Patent number
US04829081

Reaction notes

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