HRID1761977

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)CCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1

HCID62603

Methyl 3,5-bis(tert-butyl)-4-hydroxyhydrocinnamate

C18H28O3

结构：CC(C)(CO)C1OCC2(CO1)COC(C(C)(C)CO)OC2

HCID7569008

3,9-Bis(1,1-dimethyl-2-hydroxyethyl)-2,4,8,10-tetraoxaspiro[5.5]undecane

C15H28O6

HCID10942334

Methanol, sodium salt

CH3NaO

PRODUCTS

生成物

结构：CC(C)(C)c1cc(CCC(=O)OCC(C)(C)C2OCC3(CO2)COC(C(C)(C)COC(=O)CCc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)OC3)cc(C(C)(C)C)c1O

HCID16663086

未命名化合物

收率 169.7%

PROCEDURE

实验过程

A mixture of 35.3 g (0.121 mole) of methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate, 15.3 g (0.0503 mole) of 3,9-bis(2-hydroxy-1,1-dimethylethyl)-2,4,8,10-tetraoxaspiro[5.5]undecane and 0.82 g (0.015 mole) of sodium methoxide was reacted, after-treated and purified in the same manner as in Preparation example 1, to obtain 21 g of white crystalline 3,9-bis{2-[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionyloxy]-1,1-dimethylethyl}-2,4,8,10-tetraoxaspiro[5.5]-undecane having a purity of 99% (compound AO-1). m.p., 98°-100° C.

WORKUP

后处理

customwas reacted
additionafter-treated
custompurified in the same manner as in Preparation example 1

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-686f046f79484d16bc412f369479e759
来源数据集: uspto-grants-1989_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04829112
来源说明: uspto-grants-1989_05

反应 SMILES

[C:1]([C:5]1[CH:6]=[C:7]([CH2:16][CH2:17][C:18]([O:20][CH3:21])=[O:19])[CH:8]=[C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:10]=1[OH:11])([CH3:4])([CH3:3])[CH3:2].[OH:22][CH2:23][C:24]([CH:27]1[O:32][CH2:31][C:30]2([CH2:37][O:36][CH:35]([C:38]([CH3:42])([CH3:41])CO)[O:34][CH2:33]2)[CH2:29][O:28]1)([CH3:26])[CH3:25].[CH3:43][O-:44].[Na+]>>[C:1]([C:5]1[CH:6]=[C:7]([CH2:16][CH2:17][C:18]([O:20][CH2:21][C:38]([CH:35]2[O:34][CH2:33][C:30]3([CH2:29][O:28][CH:27]([C:24]([CH3:26])([CH3:25])[CH2:23][O:22][C:18](=[O:19])[CH2:17][CH2:16][C:7]4[CH:6]=[C:5]([C:1]([CH3:2])([CH3:4])[CH3:3])[C:43]([OH:44])=[C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH:8]=4)[O:32][CH2:31]3)[CH2:37][O:36]2)([CH3:42])[CH3:41])=[O:19])[CH:8]=[C:9]([C:12]([CH3:13])([CH3:14])[CH3:15])[C:10]=1[OH:11])([CH3:2])([CH3:3])[CH3:4]