HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitro-2-isopropyl-1,3-propanediol → 2-Amino-2-isopropyl-1,3-propanediol acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitro-2-isopropyl-1,3-propanediol | HCID 143881 | — |
| Reactant | (+-)(2R*,3RS,4R*)-3-Amino-3-methyl-2,4-pentanediol acetate | HCID 53919029 | — |
| Product | 2-Amino-2-isopropyl-1,3-propanediol acetate | HCID 14391248 | 98% |
Reaction Steps
Using the procedure in 5D, 2-isopropyl-2-nitro-1,3-propanediol (11A) gave a 98% yield of 2-amino-2-isopropyl-1,3-propanediol acetate mp 155°-155.5°. H. S. Broadbent et al., J. Heterocyclic Chem., 13, 337 (1975) report the synthesis of this compound as the free base (mp 70°-72° )).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04829090 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-3bb3d3d7ccc94b43acd0b77127effb22 |
| Source note | uspto-grants-1989_05 |