HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-3-aminopyrazole → HCID 14516775, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-3-aminopyrazole | HCID 137254 | — |
| Reactant | Ethyl 2-amino-2-cyanoacetate | HCID 288716 | — |
| Reactant | Ethylorthoformate | HCID 53630039 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 14516775 | HCID 14516775 | 61% |
Reaction Steps
In 200 ml of acetonitrile, 6.7 g of ethyl-aminocyanoacetate, 8.5 g of ethyl orthoformate and 5.6 g of 3-amino-1-methylpyrazole were refluxed under heating for 4.5 hours. After completion of the reaction, the solvent was distilled off under reduced pressure. Crystals precipitated was filtered out, followed by washing with ether to give 7.5 g of the desired compound. m.p.: 168° to 170° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04830660 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-82e9f32b94a94e1db6710f6fbed43b36 |
| Source note | uspto-grants-1989_05 |