HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminopyridine → HCID 14129245, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminopyridine | HCID 10439 | — |
| Reactant | Ethyl 2-amino-2-cyanoacetate | HCID 288716 | — |
| Reactant | Ethylorthoformate | HCID 53630039 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 14129245 | HCID 14129245 | 71.9% |
Reaction Steps
In 230 ml of acetonitrile, 8.5 g of ethyl α-aminocyanoacetate, 10.8 g of ethyl orthoformate and 6.2 g of 2-aminopyridine were heated under reflux for 1.5 hours. After completion of the reaction, the solvent was distilled off under reduced pressure and crystals precipitated were filtered off and washed with benzene to give 11.0 g of the desired compound. m.p.: 129° to 131° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04830660 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-b4f5b8b8ab13439689182888e5020891 |
| Source note | uspto-grants-1989_05 |