Cyanogen Bromide → HCID 135767478, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(5-aminoimidazol-4-yl)-5-phenyl-1,2,4-triazole (11.3 g, from Example 1), methanol (200 mL) and cyanogen bromide (5.25 g) is stirred under nitrogen for 2 hours at 40° C. It is cooled and the solid collected, dissolved in 10N Sodium hydroxide solution, filtered and precipitated by addition of glacial acetic acid to pH 5. The solid is washed with water, stirred in a mixture of methanesulphonic acid in methanol for one-half hour and collected (1.39 g), mp >350°. After drying at room temperature and high vacuum, the hemihydrate of 5-amino-2-phenyl-[1,2,4]triazolo[5,1-i]purine is thus obtained.

Provenance & Evidence