N-methyl-2-pyrrolidone → HCID 135767476, compound

Participants

Reaction Steps

A mixture of the tert-butyl carbamate of 2-amino-3-cyanopyridine (4.6 g), 2-furoylhydrazine (2.65 g) and 1-methyl-2-pyrrolidone (46 mL) is heated at 160° over 18 hr. It is cooled and diluted with water (369 mL) to afford 2-(2-furyl)pyrido-[3,2-e][1,2,4]-triazolo[1,5-c]pyrimidin-5(6H)one in 53% yield. It is purified by tituration in hot methanol, which removes the soluble impurities, and melts above 360° C.

Provenance & Evidence