HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl carbamate → 2-(2-fluorophenyl)-pyrido[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl carbamate | HCID 77922 | — |
| Reactant | 2-Fluorobenzhydrazide | HCID 136288 | — |
| Reactant | 3-Aminopyridine-4-carbonitrile | HCID 10678219 | — |
| Product | 2-(2-fluorophenyl)-pyrido[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)one | HCID 135503570 | 78% |
Reaction Steps
When the tert-butyl carbamate of 3-amino-4-cyanopyridine replaces the urethane described in Example 37 and o-fluorobenzhydrazide replaces 2-furoylhydrazine in the same example, 2-(2-fluorophenyl)-pyrido[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)one is obtained in 78% yield, m.p. 324°-326°. It is purified as the membrane sulphonate salt, m.p. 285° to 287°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04831013 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-83f4729b8bd846a3805dcca4f897b59b |
| Source note | uspto-grants-1989_05 |