Sodium Hydroxide → [1,2,4]TRIAZOLO[1,5-C]PYRIMIDIN-5-OL

HRID 1762080Notes

Reaction equation

HRID 1762080 reaction equation
C(CN1CC[C:13]2[NH:12][C:11](=[O:16])[N:10]3[N:17]=[C:18](C4C=CC=CC=4F)[N:19]=[C:9]3[C:8]=2C1)(OC)=O.[OH-].[Na+]>C(O)C>[N:19]1[CH:18]=[N:17][N:10]2[C:9]=1[CH:8]=[CH:13][NH:12][C:11]2=[O:16]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 135767479HCID 135767479, compound

Product 1

HCID 135767466[1,2,4]TRIAZOLO[1,5-C]PYRIMIDIN-5-OL

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of the product of Example 42 (500 mg) in ethanol (20 mL) is added 4N aqueous sodium hydroxide (1 mL) and the whole stirred at reflux under nitrogen for 2 hours. It is cooled, filtered and the filtrate neutralized with glacial acetic acid with ice cooling to produce the solid 9-carboxymethyl-2-(2-fluorophenyl)-7,8,9,10-tetrahydropyrido[3,4-e][(1,2,4]triazolo[1,5-c]pyrimidin-5(6H)one.

Workup

  1. temperatureat reflux under nitrogen for 2 hours
  2. temperatureIt is cooled
  3. filtrationfiltered

Sources & evidence

ORD record
ord-539c5bf085cc4872b7dbfa660ca8788c
Source dataset
uspto-grants-1989_05
Patent number
US04831013

Reaction notes

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