Ammonium Chloride → HCID 178518576, compound

Participants

Reaction Steps

A mixture of the product of Example 50 (640 mg), sodium azide (1.41 g), ammonium chloride (120 mg) and dimethylformamide (10 mL) is stirred at 90° over 3 hours under nitrogen. The mixture is cooled and quenched in ice-water (40 mL), stirred 1/2 hour, and cautiously acidified with glacial acetic acid to afford the solid product 2-(2-fluorophenyl)-9-tetrazolylmethyl-7,8,9,10-tetrahydropyrido[3,4-e][1,2,4]triazolo[1,5-c]pyrimidine-5(6H)one.

Provenance & Evidence