Dimethylformamide → HCID 178459974, compound

Participants

Reaction Steps

To a mixture of 0.50 g (0.005 mole, 0.69 ml) of triethyl amine, 4 ml of dimethyl formamide, 1 ml of hexamethyl phosphoric triamide and 0.828 g (0.003 mole) of 2-morpholino-6,7,8,9-tetrahydro-pyrido[4,3-d]-1,2,4-triazolo[1,5-a]-pyrimidine-5(10H)-one are added. To the mixture 0.46 g (0.005 mole, 0.43 ml) of propionyl chloride are added under stirring and the reaction mixture is first stirred at 25° C. for six hours and a half and then allowed to stand at room temperature for 16 hours. After addition of 25 ml of water the precipitated crystals are filtered and washed with acetone. The solid is dissolved in 6 ml of hot dimethyl formamide and precipitated by adding 15 ml of acetonitrile. Thus 0.63 g of the desired compound is obtained, yield 63%, m.p.: 278°-280° C.

Provenance & Evidence