Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Naphthoquinone | HCID 8530 | — |
| Reactant | 2-Formyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid | HCID 12324171 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Product | Mitoquidone | HCID 71772 | — |
Reaction Steps
A mixture of 2-formyl-3-carboxy-1,2,3,4-tetrahydroisoquinoline (20 g) and 1,4-naphthoquinone (30.8 g) in acetic anhydride (500 ml) was heated at 100° C. with stirring for 30 minutes. The reaction mixture was cooled, the solid collected by filtration, washed with acetic anhydride (50 g) with ether (2×100ml) and dried to give the title compound in Form B (26 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04831039 |
|---|
| Source dataset | uspto-grants-1989_05 |
|---|
| ORD ID | ord-3e6c57dee69d483db1b29de38c740d3c |
|---|
| Source note | uspto-grants-1989_05 |
|---|
