反应详情

A mixture of 5-chloro-7-amino-8-hydroxyquinoline (6 g, 30.8 mol) and methyl trimethoxyacetate (16.3 g, 123.2 mol) was heafted at 100° C. overnight. The reaction was cooled in an ice bath and filtered. The precipitate was dissolved in acetone (250 ml). The resulting solution was treated with charcoal at reflux, filtered through a pad of silica gel and celite and partially concentrated. Crystals formed which were filtered and dried giving 4.1 g (51% yield) of solid. M.P. 217° C. to 218° C.

1. temperatureThe reaction was cooled in an ice bath
2. filtrationfiltered
3. dissolutionThe precipitate was dissolved in acetone (250 ml)
4. additionThe resulting solution was treated with charcoal
5. temperatureat reflux
6. filtrationfiltered through a pad of silica gel and celite
7. concentrationpartially concentrated
8. customCrystals formed which
9. filtrationwere filtered
10. customdried