Ethyl chloroformate → HCID 14210632, compound

HRID 1762118Notes

Reaction equation

HRID 1762118 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][CH2:12][CH2:11][N:10]([C:14](=[O:19])[C:15]([F:18])([F:17])[F:16])[CH2:9]1.Cl[C:21]([O:23][CH2:24][CH3:25])=[O:22]>C(Cl)Cl.N1C=CC=CC=1>[CH2:24]([O:23][C:21](=[O:22])[NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][CH2:12][CH2:11][N:10]([C:14](=[O:19])[C:15]([F:18])([F:16])[F:17])[CH2:9]1)[CH3:25]

Participants

5

Reactant 2

HCID 10928Ethyl chloroformateHCID 14210631HCID 14210631, compound

Product 1

HCID 14210632HCID 14210632, compound

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6344DichloromethaneSolvent

Procedure

2.2 g of 3-(2-aminophenyl)-1-(trifluoroacetyl)-piperidine in 100 ml of methylene chloride, 3 ml of pyridine and 1 ml of ethyl chloroformate were stirred for one hour, washed with 2N hydrochloric acid and then with water, dried, taken to dryness under reduced pressure to obtain 2.8 g of an oil which was used as is for the following step.

Workup

  1. washwashed with 2N hydrochloric acid
  2. dry with materialwith water, dried

Sources & evidence

ORD record
ord-583c500604ce4452bee91c515b942aef
Source dataset
uspto-grants-1989_05
Patent number
US04831043

Reaction notes

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