HCID 14210633, compound → HCID 14210634, compound

HRID 1762120Notes

Reaction equation

HRID 1762120 reaction equation
[CH2:1]([O:3][C:4](=[O:27])[NH:5][C:6]1[C:11]([CH:12]2[CH2:17][CH2:16][CH2:15][N:14]([C:18](=[O:23])[C:19]([F:22])([F:21])[F:20])[CH2:13]2)=[CH:10][CH:9]=[CH:8][C:7]=1[N+:24]([O-])=O)[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:27])[NH:5][C:6]1[C:11]([CH:12]2[CH2:17][CH2:16][CH2:15][N:14]([C:18](=[O:23])[C:19]([F:20])([F:22])[F:21])[CH2:13]2)=[CH:10][CH:9]=[CH:8][C:7]=1[NH2:24])[CH3:2]

Participants

4

Reactant 1

HCID 14210633HCID 14210633, compound

Product 1

HCID 14210634HCID 14210634, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

12 g of the product of Step D were hydrogenated for 3 hours in 400 ml of ethanol in the presence of 3 g of palladium at 10% on carbon. After filtering, washing with ethanol and evaporating to dryness under reduced pressure, 10.8 g of ethyl-[2-amino-6-[1-(trifluoroacetyl)-3-piperidinyl]-phenyl]-carbamate melting at about 90° C. after crystallization from isopropyl ether were obtained.

Workup

  1. filtrationAfter filtering
  2. washwashing with ethanol
  3. customevaporating to dryness under reduced pressure, 10.8 g of ethyl-[2-amino-6-[1-(trifluoroacetyl)-3-piperidinyl]-phenyl]-carbamate melting at about 90° C.
  4. customafter crystallization from isopropyl ether
  5. customwere obtained

Sources & evidence

ORD record
ord-55aa3e47e2e54fa1ae1e470643793bc1
Source dataset
uspto-grants-1989_05
Patent number
US04831043

Reaction notes

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