HCID 14210634, compound → HCID 14210635, compound

Participants

Reaction Steps

4 g of the product of Step E in 80 ml of methanol, 16 ml of water and 16 ml of potassium hydroxide were taken to 80° C. for 4 hours with stirring under an inert atmosphere. After evaporating the methanol under reduced pressure, adding 30 ml of water, adjusting the pH to 6-8 by acetic acid and taking to dryness under reduced pressure, the residue was purified by chromatography on silica, (eluent: methylene chloride-methanol-triethylamine (6-3-1) to obtain 2.15 g of crude product. The latter was triturated in ethyl ether, separated, dried and crystallized from ethanol to obtain 1.23 g of 1,3-dihydro-4-(3-piperidinyl)-2H-benzimidazol-2-one melting at about 260° C.

Provenance & Evidence