Acetate → alpha-Hydroxyacetophenone

Participants

Reaction Steps

To a solution of 755 mg of the thus-obtained acetate in nitrobenzene were added 456 mg of finely divided AlCl3, and the mixture was heated for one hour at 120°-125° C. The reaction mixture was diluted by water and extracted with ethyl acetate. The extracted solution was washed with water, sodium hydrogencarbonate solution, water, and saturated saline solution in series and dried over MgSO4. The distillation of the solvent and purification by chromatography through silica gel column gave 490 mg (yield: 64.9%) of the 2-hydroxyacetophenone.

Provenance & Evidence