反应详情

A mixture of dimethyl (α-amino-3-nitrobenzylidene)malonate (120 g) and potassium hydroxide in a mixture of methanol (1.2 l) and water (120 ml) was refluxed for 8 hours. The reaction mixture was concentrated under reduced pressure to a volume of 200 ml. The resulting crystals were collected by filtration and recrystallized from methanol to give methyl 3-amino-3-(3-nitrophenyl)acrylate (50.2 g).

1. temperaturewas refluxed for 8 hours
2. concentrationThe reaction mixture was concentrated under reduced pressure to a volume of 200 ml
3. filtrationThe resulting crystals were collected by filtration
4. customrecrystallized from methanol