Methylparaben → Methyl 4-(2-aminoethoxy)benzoate

Participants

Reaction Steps

Methyl p-hydroxybenzoate (7.6 g) was dissolved in 50 ml of chloroform with heating, 2.15 g of aziridine was dropped in with stirring, and the mixture was heated to refluxed for 8 hours. The reaction solution was concentrated in vacuo and the residue was purified by a silica gel column chromatography (200 g of silica gel C-200; the eluting solvent used was a 9:1 mixture of chloroform and methanol).

Provenance & Evidence