Triethylamine → 1-(4-Isopropylbenzoyl)aziridine

HRID 1762172Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1762172
[NH:1]1[CH2:3][CH2:2]1.C(N(CC)CC)C.[CH:11]([C:14]1[CH:22]=[CH:21][C:17]([C:18](Cl)=[O:19])=[CH:16][CH:15]=1)([CH3:13])[CH3:12]>C1C=CC=CC=1>[CH:11]([C:14]1[CH:15]=[CH:16][C:17]([C:18]([N:1]2[CH2:3][CH2:2]2)=[O:19])=[CH:21][CH:22]=1)([CH3:13])[CH3:12]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 9033AziridineHCID 27594864-Isopropylbenzoyl chloride

Produkt 1

HCID 144266221-(4-Isopropylbenzoyl)aziridineAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

Aziridine (4.52 g) and 10.62 g of triethylamine were dissolved in 200 ml of benzene. p-Isopropylbenzoyl chloride (18.26 g) was dropped thereinto with stirring and keeping the inner temperature at 4° to 5° C. After the dropping, the mixture was stirred for 2 hours at the same temperature. After the reaction, the insoluble matters were removed by filtration, the filtrate was concentrated in vacuo, and the residue was purified by a silica gel column chromatography (300 g of silica gel C-200; the eluting solvent was chloroform) to give 17.70 g of the product, yield: 94%.

Aufarbeitung

  1. customat 4° to 5° C
  2. stirringAfter the dropping, the mixture was stirred for 2 hours at the same temperature
  3. customAfter the reaction
  4. customthe insoluble matters were removed by filtration
  5. concentrationthe filtrate was concentrated in vacuo
  6. customthe residue was purified by a silica gel column chromatography (300 g of silica gel

Quellen und Nachweise

ORD-Eintrag
ord-587d25654a234bd68661dbbb445d3e17
Quelldatensatz
uspto-grants-1989_05
Patentnummer
US04831055

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