反应详情

Aziridine (4.52 g) and 10.62 g of triethylamine were dissolved in 200 ml of benzene. p-Isopropylbenzoyl chloride (18.26 g) was dropped thereinto with stirring and keeping the inner temperature at 4° to 5° C. After the dropping, the mixture was stirred for 2 hours at the same temperature. After the reaction, the insoluble matters were removed by filtration, the filtrate was concentrated in vacuo, and the residue was purified by a silica gel column chromatography (300 g of silica gel C-200; the eluting solvent was chloroform) to give 17.70 g of the product, yield: 94%.

1. customat 4° to 5° C
2. stirringAfter the dropping, the mixture was stirred for 2 hours at the same temperature
3. customAfter the reaction
4. customthe insoluble matters were removed by filtration
5. concentrationthe filtrate was concentrated in vacuo
6. customthe residue was purified by a silica gel column chromatography (300 g of silica gel