反应详情

Methyl 4-[2-(4-isopropylbenzamido)ethoxy]benzoate (102.42 g) was dissolved in 1 liter of ethanol with heating. A solution of 14.4 g of sodium hydroxide in 200 ml of water was added to the above ethanolic solution and the mixture was heated to reflux for 2 hours. The reaction solution was concentrated in vacuo, 1 liter of ice water was added to the residue, the mixture was neutralized with 10% hydrochloric acid, crystals separated out therefrom were collected by filtration, washed with water, dried and recrystallized from ethanol to give 80.5 g (yield: 82%) of crystalline product. M.p. 202°-203° C.

1. temperaturewith heating
2. temperaturethe mixture was heated
3. temperatureto reflux for 2 hours
4. concentrationThe reaction solution was concentrated in vacuo, 1 liter of ice water
5. additionwas added to the residue
6. customseparated out
7. filtrationtherefrom were collected by filtration
8. washwashed with water
9. customdried
10. customrecrystallized from ethanol