Sodium Hydroxide → HCID 23696205, compound

HRID 1762182Notes

Reaction equation

HRID 1762182 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]2[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][CH:13]=2)=[O:7])=[CH:4][CH:3]=1.[OH-].[Na+:24]>CO.O>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]2[CH:13]=[CH:14][C:15]([C:16]([O-:18])=[O:17])=[CH:19][CH:20]=2)=[O:7])=[CH:4][CH:3]=1.[Na+:24]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 14097620HCID 14097620, compound

Product 1

HCID 23696205HCID 23696205, compoundYield 67.5%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

4-[2-(4-Chlorobenzamido)ethoxy]benzoic acid (3.19 g) was dissolved in 50 ml of methanol. A solution of 0.40 g of sodium hydroxide in 5 ml of water was added to the above methanolic solution, the mixture was concentrated in vacuo, the crystallised residue was recrystallised from methanol, and 2.30 g of crystalline product was obtained. M.p. not lower than 300° C.

Workup

  1. concentrationthe mixture was concentrated in vacuo
  2. customthe crystallised residue was recrystallised from methanol

Sources & evidence

ORD record
ord-7e8012addffb42ebaf1dfa9b403020ac
Source dataset
uspto-grants-1989_05
Patent number
US04831055

Reaction notes

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